OUR PERSPECTIVE
Shortcomings of existing therapies
Current standard of care treatments are ineffective for millions worldwide.
Limited Efficacy
Slow onset – Up to 3 months for SSRIs to take full effect
Trial and error – Remission with first selected SSRI occurs only 30% of the time
Low response rate – Only 50% respond within 8 weeks and ~33% become treatment-resistant
High relapse rate – ~75% of patients undergoing OUD therapy experience relapse within 1 year
Side Effects
Addiction – Long-term benzodiazepine use is associated with development of drug dependence
Sexual dysfunction – Side effects of SSRIs include sexual dysfunction
Weight gain – Patients on SSRIs can experience weight gain
Sleep – SSRIs interfere with sleep architecture, potentially complicating the sleep of depressed patients
Our unique approach
Compounds with prior evidence in humans
To minimize development risk, we focus on compounds that have previously been used in humans and have established safety profiles.
Enabling platform technologies
Decentralized drug development
In addition to funding, our evolving companies have access to our deep domain expertise and operational backbone.
Learn more about our approach
OUR MODELWHERE WE’RE HEADED
Our technologies drive efficient drug discovery and improved treatment outcomes.
Our unique model combines funding with operational expertise to develop innovative and impactful CNS therapeutics.
OUR MODELNews & Insights
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